S2 EPISODE 49 - Low-Carb Diets and Cholesterol, LDL-C & Heart Disease Risk w/ Dr. David Diamond PhD

Season 2 Episode 49, Dr. Bubbs interviews expert Dr. David Diamond PhD to talk about cholesterol, LDL-cholesterol, saturated fats and heart disease risk. In this episode, David reviews the history of our modern fear of cholesterol, statistical misrepresentation in the early research on cholesterol and heart disease risk, and whether he believes the evidence supports saturated fat as a risk factor for heart disease. David also discusses the original research on statins, reviews the literature on LDL-c, and how much they actually impact heart disease risk. As well, David highlights the importance of LDL particle number and the fundamental role of clotting in the pathogenesis of atherosclerosis. 

Summary of This Episode

3:00 – Our modern fear of cholesterol

4:30 – Original trials using corn oil to treat high cholesterol

6:00 – Research in the 1980s – Statistical misrepresentation

11:00 – Time Magazine Cover 1984 – Cholesterol causes heart disease

12:45 – Saturated fat and heart disease risk

17:00 -  Does saturated fat increase risk of heart disease?

21:00 – Statins – original research

25:30 – Relative vs. absolute risk

29:00 – Research review on LDL and risk of CVD

32:00 – LDL particle number and CVD risk

34:30 – ApoB, Lp(a), coagulation and trigger of atherosclerosis

40:00 – Lifestyle factors and CVD risk

43:00 – Can a low-fat diet in a caloric deficit achieve the same heart healthy effects

46:30 – Evolution of research in heart disease

Research Papers

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review.

About Dr. David Diamond PhD

Dr. David Diamond PhD is a neuroscientist and professor at the University of South Florida. David is the former director of the University's Center for Preclinical and Clinical Research on PTSD. David also developed a special interest in cardiovascular research when confronted with a health crisis over a decade ago and currently contributes to research and delivers educational talks to doctors in this space. Follow David on Twitter @LDLsceptic